When installing Trend Micro OfficeScan to a desktop it creates a globally unique identifier. This is a problem in environments where you're cloning disks with disk imaging tools (such as Ghost) or in a VMware View environment when you're using an automated desktop pool with a single parent vm.

Trend has a kb article on this topic meant for disk imaging solutions:

http://esupport.trendmicro.com/8/Deploying-OfficeScan-80-clients-using-disk-imaging.aspx

The steps in the above article also works on OfficeScan 10, but after logging on it shows a window telling you that OfficeScan is being reconfigured that is shown for a minute or two. This is probably not so important in a traditional disk cloning environment where you're doing this only once in a clients life time, but things are different when you need to run this everytime a user logins. Note that this solution is only available for 32 bit guests.

The following is from Trend Micro OfficeScan 10's help on this topic:

 

The solution we've found for a VMware View environment is this:

1. Power on the parent VM
2. Copy the imgsetup.exe file from the OfficeScan server to the parent VM
3. Login to the parent VM and run imgsetup.exe /silent
4. Shutdown the parent VM and create a new snapshot
5. From Desktops and Pools in View Manager you need to create a new Automated Pool that points to your new snapshot
6. Entitle it and it's ready for action

You will need to run this command (imgsetup /silent) every time you change the parent VM image.